One of the larger transitions from Dungeons and Dragons or Pathfinder to the Cypher System is the way that it handles skills. In the former systems, skills are detailed and have a relatively narrow range of applications. These skills are drawn from a specific list that is tailored to the experience of the game (say a high fantasy adventure game).
The Cypher System takes a different approach. While there are lists of suggested skills, the lists are open-ended. Instead of having a narrowly defined application (or set of applications) for the skills, the skills are defined in play. You can invoke them when they may assist you with a particular challenge -- and the boundaries of application are up to your table. This is a relatively open approach to skills. For a related discussion see Marc Plourde's discussion of skill systems on his blog
Inspiration Strikes!. The recent fantasy RPG 13th Age provides an interesting approach to skills that may inspire your own character development with The Strange or other Cypher System games.